发明名称 |
Medical Implants and Methods of Making Medical Implants |
摘要 |
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
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申请公布号 |
US2011159069(A1) |
申请公布日期 |
2011.06.30 |
申请号 |
US20090648106 |
申请日期 |
2009.12.28 |
申请人 |
SHAW WENDY J;YONKER CLEMENT R;FULTON JOHN L;TARASEVICH BARBARA J;MCCLAIN JAMES B;TAYLOR DOUG |
发明人 |
SHAW WENDY J.;YONKER CLEMENT R.;FULTON JOHN L.;TARASEVICH BARBARA J.;MCCLAIN JAMES B.;TAYLOR DOUG |
分类号 |
A61F2/02;A61F11/00;A61K31/727;A61K38/16;A61P43/00 |
主分类号 |
A61F2/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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