发明名称 |
SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS |
摘要 |
This invention is related to new histone deacetylase inhibitors according to the general formula (I), wherein: m and n are independently zero or an integer from 1 to 4; p is zero or an integer from 1 to 3, with the proviso that when p is zero, n and m cannot be both 1; R is hydrogen; C1-C6 alkyl, optionally substituted by C3-C8 cycloalkyl, C6-C10 aryl or hetero(C2-C9)aryl; (CO)R2; (SO2)R3; C3-C8 cycloalkyl; C6-C10 aryl; or hetero(C2-C9)aryl; R1 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy; Y is CH2 or NR4; Z is C=R5; and R2, R3, R4, and R5 are as further defined in the specification; and pharmaceutical acceptable salts thereof. |
申请公布号 |
WO2011045265(A3) |
申请公布日期 |
2011.06.30 |
申请号 |
WO2010EP65176 |
申请日期 |
2010.10.11 |
申请人 |
DAC S.R.L.;VARASI, MARIO;THALER, FLORIAN;AMICI, RAFFAELLA;ABATE, AGNESE;FULCO, MARIA CARMELA;MINUCCI, SAVERIO;MERCURIO, CIRO |
发明人 |
VARASI, MARIO;THALER, FLORIAN;AMICI, RAFFAELLA;ABATE, AGNESE;FULCO, MARIA CARMELA;MINUCCI, SAVERIO;MERCURIO, CIRO |
分类号 |
C07D491/10;A61K31/35;A61K31/407;A61K31/438;A61K31/537;A61K31/55;C07D498/10 |
主分类号 |
C07D491/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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