ANTI-FLT3 ANTIBODIES AND METHODS OF USING THE SAME

摘要

The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitututions 239D and 332E to enhance antibody- dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.