ANTIBODIES WITH MANNOSE BINDING LECTIN EFFECTOR FUNCTION FOR INHIBITING PATHOLOGIC INFLAMMATORY CONDITIONS

摘要

The invention provides compositions comprising monoclonal antibodies which have variable regions that bind an antigen exposed on dead or dying cells and have constant region sequence that contains at least one site which is glycosylated. The antibodies have sufficient type and number of glycans that are ligand for mannose binding lectin (MBL), Administration of the antibodies to individuals suffering from a pathological inflammatory condition treats or inhibits the inflammation via recruitment of MBL.