Piperidinyl derivatives as modulators of chemokine recepteor activity

摘要

Disclosed are piperidinyl derivatives represented by formula (Ib) or (Ib'), or stereoisomers or pharmaceutically acceptable salts thereof, wherein T is -C(O)- or -C(O)-NR8- and R2 is an optionally substituted alkyl. Also disclosed is the use the compounds of formula (Ib) or (Ib') in the preparation of a medicament for treating a disorder selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, hysically or chemically induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerularnephritis, asthma, multiple sclerosis, artherosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.