摘要 |
The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R, and R are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER, JEAN-DAMIEN;DURRANT, STEVEN;KAY, DAVID;O'DONNELL, MICHAEL;KNEGTEL, RONALD;MACCORMICK, SOMHAIRLE;PINDER, JOANNE;VIRANI, ANISA;YOUNG, STEPHEN;BINCH, HAYLEY;CLEVELAND, THOMAS;FANNING, LEV T.D.;HURLEY, DENNIS;JOSHI, PRAMOD;SHETH, URVI;SILINA, ALINA;REAPER, PHILIP MICHAEL |