| 摘要 |
The invention relates to new 5-thioxylose compounds, preferably 5-thioxylopyranose type derivatives, and the method of preparation thereof and their use as active ingredient for drugs, in particular intended for treatment or prevention of thromboses. The compounds have formula (I)in which the pentapyranosyl group represents a free or substituted 5-thio-&bgr;D-xylopyranosyl group; R', R'' and R''' each independently represent a hydrogen atom, a C2-C6 acyl group or two of them, adjacent from R', R'' and R''', form a 1-methylethylidene bridge; X1 and X2 each represent a carbon or nitrogen atom; Y1 and Y2 each represent independently of each other a carbon, nitrogen, sulfur or oxygen atom, with the condition that if Y2 represents an oxygen or sulfur atom, Y1 represents a carbon or nitrogen atom; R1, R2, R3, R4 and R5 represent, independently of each other, a hydrogen atom, a –COOR6 group where R6 represents a hydrogen atom or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a –COOR6 group, an C1-C4 alkoxy group, a C2-C6 acyl group, a benzoyl group or a phenyl ring; and addition salts of the compounds having the formula (I) and the active metabolites of the compounds having the formula (I). |
