COMPOSITION FOR DIAGNOSIS AND DETERMINATION OF PROGNOSIS OF HEPATOCELLULAR CARCINOMA

摘要

The present invention relates to a composition for the diagnosis and determination of the prognosis of hepatocellular carcinoma, and more particularly to a composition for the diagnosis of hepatocellular carcinoma comprising the Ephrine A1 (EFNA1) gene or a protein expressed from the EFNA1 gene and a composition for the determination of the prognosis of hepatocellular carcinoma comprising the EPHA2 gene which is a receptor for EFNA1 or a protein expressed from the EPHA2 gene. The present invention is a marker for diagnosing hepatocellular carcinoma using Ephrine A1 (EFNA1) and its receptor, EPHA2, and can be useful for a biomarker for the diagnosis and determination of the prognosis of hepatocellular carcinoma. The present invention can diagnose hepatocellular carcinoma early by providing the EFNA1 gene and the EPHA2 gene and effectively detecting the expression of a protein which is the EFNA1 gene product in a body fluid. The present invention can quantify the EPHA2 gene expression as a tumor marker in patients' tissues quickly and sensitively and be useful for determining the prognosis of hepatocellular carcinoma progress, that is, the invasive and metastatic potential.