发明名称 |
Dock-and-Lock (DNL) Complexes for Therapeutic and Diagnostic Use |
摘要 |
Disclosed herein are methods and compositions dock and lock (DNL) complexes comprising an AD moiety selected from an AKAP protein and a DDD moiety selected from a protein kinase A regulatory subunit. Also disclosed are fusion proteins comprising an AD moiety or DDD moiety attached to an effector moiety. The DDD moieties form dimers that bind to the AD moiety to form the DNL complexes. The effector moieties may be selected from a wide range of known effector moieties that produce one or more physiological effects, including but not limited to cell death. The DNL complexes may further comprise one or more diagnostic and/or therapeutic agents. The DNL complexes are of use for treating and/or diagnosing a variety of diseases or conditions.
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申请公布号 |
US2011158905(A1) |
申请公布日期 |
2011.06.30 |
申请号 |
US201113036820 |
申请日期 |
2011.02.28 |
申请人 |
IBC PHARMACEUTICALS, INC. |
发明人 |
GOLDENBERG DAVID M.;CHANG CHIEN-HSING |
分类号 |
A61K51/10;A61K39/395;A61K49/00;A61P9/00;A61P25/28;A61P35/00;A61P35/02;A61P37/02;C07K14/00;C07K14/475;C07K14/505;C07K14/52;C07K14/525;C07K14/54;C07K14/55;C07K14/555;C07K14/56;C07K14/565;C07K14/57;C07K14/575;C07K14/61;C07K14/765;C07K16/00;C12N9/22 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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