| 摘要 |
Disclosed is a process for preparing (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol, or an acid addition salt thereof, comprising the step of (a) reacting a compound of general formula (I), wherein R represents -C1-6-alkyl, -C3-8-cycloalkyl, -C1-3-alkylene-phenyl, -C1-3-alkylene-naphthyl, tetrahydropyranyl or -C(=O)-C1-6-alkyl, with ethyl magnesium halide in an inert reaction medium under Grignard conditions; (b) transferring the thus obtained compound of general formula (II), to a compound of general formula (III), optionally in form of an acid addition salt; (c) deprotecting the thus obtained compound of general formula (III) to obtain (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol of formula (IV); (d) optionally converting the thus obtained (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol into an acid addition salt. |
