Methods and compositions for modulating stem cell growth and differentiation

摘要

The invention can be summarized as follows. There is provided methods and compositions for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted or to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.