发明名称 |
WATER-SOLUBLE NANOSTRUCTURE FOR PHOTODYNAMIC THERAPY |
摘要 |
PURPOSE: A soluble nanostructure containing soluble porphyrin derivatives is provided to ensure high photodynamic therapeutic agent and to prevent side effects. CONSTITUTION: A soluble nanostructure for photodynamic therapy contains soluble porphyrin derivative of chemical formula 1. The porphyrin derivative is prepared by amidation of protoporphyrin IX(chemical formula 2) with polyethylene glycol derivatives(chemical formulas 3 and 4) of amino terminal. A coupling agent for amidation is 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDC), N,N'-dicyclohexylcarbodiimide(DCC), or N,N'-diisopropylcarbodiimide(DIC).
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申请公布号 |
KR20110073731(A) |
申请公布日期 |
2011.06.30 |
申请号 |
KR20090130454 |
申请日期 |
2009.12.24 |
申请人 |
DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
JEONG, SANG WON;LEE, SE GEUN;KIM, HYUN CHUL;KIM, EUN JOO;LEE, SUNG JUN;BAEK, CHUL SU;LEE, HYUN JU |
分类号 |
C07D487/22;A61K31/409;A61P35/00 |
主分类号 |
C07D487/22 |
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