<p>The present invention includes compositions and methods to attenuate the immunosuppressive activity of TGF-ß through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.</p>
申请公布号
WO2011079070(A1)
申请公布日期
2011.06.30
申请号
WO2010US61309
申请日期
2010.12.20
申请人
GRADALIS, INC.;NEMUNAITIS, JOHN, J.;SENZER, NEIL;MAPLES, PHILLIP, B.;RAO, DONALD
发明人
NEMUNAITIS, JOHN, J.;SENZER, NEIL;MAPLES, PHILLIP, B.;RAO, DONALD