| 摘要 |
Disclosed are 4-oxo-thieno[3,2-d]pyrimidine derivatives as respresented by the general formula (I), wherein; R1 is independently selected from the group consisting of hydrogen, halogen, alkyl, cycloalkyl, phenyl, naphthyl, CF3, CN, NR7R7, OR6 and SR6; R2 is selected from the group consisting of hydrogen and alkyl; R4 is G-D2-Zn; G is selected from the group consisting of O, S or CR7R7; D2 is selected from the group consisting of a direct bond, alkyl, cycloalkyl and a 4 to 6-membered non-basic heterocycle; Z is selected from the group consisting of hydroxyl, cycloalkyl, cycloalkoxy, OCOR6, CN, OSO2R6, SR6, SOR6, SO2R6, CO2R7, OPO(OR6)2 and COR6; m is an integer from 0 to 1; n is an integer from 1 to 3; and wherein the other substituents are as defined herein. The compounds are useful as pharmaceutical active agents, and particularly as melanin concentrating hormone receptor-1 antagonists.
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