<p>The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1 -carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.</p>
申请公布号
IL211809(D0)
申请公布日期
2011.06.30
申请号
IL20110211809
申请日期
2011.03.17
申请人
ASTRAZENECA UK LIMITED;MICHAEL, KARL BECHTOLD;CLAUDIA, BETTINA PACKHAEUSER;JULIE, KAY CAHILL;KATJA, MAREN FASTNACHT;BERND, HARALD LIEPOLD;KIERAN, JAMES LENNON;BENEDIKT STEITZ