The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-1RAcP in order to increase the amount of a soluble IL-1RAcP.Theinvention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.
VAN OMMEN, GARRIT-JAN BOUDEWIJN;AARTSMA-RUS, ANNEMIEKE;VAN DEUTEKOM, JUDITH CHRISTINA THEODORA;DE KIMPE, JOSEPHUS JOHANNES;VERBEEK, JOSEPH STEPHAN;YILMAZ-ELIS, ALIYE SEDA
