发明名称 |
Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low pH and methods of use thereof |
摘要 |
A novel solid composition and methods for making and using the solid composition are provided. The solid composition comprises: (a) at least one active agent with a solubility of less than about 0.3 mg/ml in an aqueous solution with a pH of at most about 6.8 at a temperature of about 37C; and (b) a hydrophilic polymer matrix composition comprising: i) a hydrophilic polymer selected from the group consisting of METHOCELTM, POLYOX WSR 1105 and combinations thereof; and optionally ii) a hydrophobic polymer selected from the group consisting of Ethocel 20 premium; and (c) an alkalizer selected from the group consisting of calcium carbonate, magnesium oxide heavy and sodium bicarbonate; wherein the composition provides at least about 70% release of the active between about 7 to about 12 hours following oral administration. |
申请公布号 |
AU2009313867(A1) |
申请公布日期 |
2011.06.30 |
申请号 |
AU20090313867 |
申请日期 |
2009.11.13 |
申请人 |
PATHEON INC.;PORTOLA PHARMACEUTICALS, INC. |
发明人 |
RAMANI, CHANDIR;WANG, JUAN;KANE, ANIL;CHOW, KWOK;LAMBING, JOE |
分类号 |
A61K9/20;A61K31/19;A61K31/192;A61K31/405;A61K31/517;A61P7/02;A61P9/00 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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