发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition. |
申请公布号 |
SG171676(A1) |
申请公布日期 |
2011.06.29 |
申请号 |
SG20110033404 |
申请日期 |
2007.05.10 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
TAN PAMELA;BRAMLAGE BIRGIT;FRANK-KAMENETSKY MARIA;FITZGERALD KEVIN;AKINC AKIN;KOTELIANSKI VICTOR E. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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