发明名称 |
Method of forming hydromorphinone compositions |
摘要 |
<p>A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial absence of hydrogen gas. Also disclosed is a method of forming a pharmaceutical composition comprising a hydromorphone salt, 8-hydroxy hydromorphone and dihydromorphone by heating an aqueous mixture of said salt, 8-hydroxy hydromorphone and dihydromorphone for a time sufficient to reduce the concentration of 8-hydroxy hydromorphone to less than about 1.0%. The methods are useful for preparing hydromorphone or hydrocodone compositions having novel impurity profiles.</p> |
申请公布号 |
EP2338891(A2) |
申请公布日期 |
2011.06.29 |
申请号 |
EP20100171268 |
申请日期 |
2000.11.09 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
HARCLERODE, WILLIAM, H.;GAULT, ROBERT;SANDISON, MARK, D. |
分类号 |
C07D489/02;A61K31/485;A61P25/04 |
主分类号 |
C07D489/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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