发明名称 |
DEVICES, APPARATUS AND METHOD FOR PROVIDING PHOTOSTIMULATION AND IMAGING OF STRUCTURES |
摘要 |
<p>According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI-glutamate and/or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications.</p> |
申请公布号 |
EP2337489(A1) |
申请公布日期 |
2011.06.29 |
申请号 |
EP20090816957 |
申请日期 |
2009.09.25 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
NIKOLENKO, VOLODYMYR;YUSTE, RAFAEL;WATSON, BRENDON, O.;PETERKA, DARCY |
分类号 |
G01N21/64;A61N5/06;G01N21/65;G02B21/00;G02B27/46 |
主分类号 |
G01N21/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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