发明名称 |
Inhibition of FGF signaling |
摘要 |
Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
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申请公布号 |
US7968527(B2) |
申请公布日期 |
2011.06.28 |
申请号 |
US20050057390 |
申请日期 |
2005.02.11 |
申请人 |
BOSTON BIOMEDICAL RESEARCH INSTITUTE |
发明人 |
EMERSON, JR. CHARLES P.;AI XINGBIN |
分类号 |
C12N5/00;A61K31/727;A61K38/00;A61K38/18;A61K38/46;C12N9/14 |
主分类号 |
C12N5/00 |
代理机构 |
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主权项 |
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地址 |
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