NOVEL GENES ENCODING β-DEFENSIN OF OLIVE FLOUNDER AND USES THEREOF

摘要

PURPOSE: A novel gene encoding Paralichthys olivaceus-derived beta-defensin is provided to ensure high antibacterial activity and to develop natural antibiotics. CONSTITUTION: A Paralichthys olivaceus-derived antibacterial peptide is a polymepeptide, mutant thereof, or active fragment thereof. The polypeptide is selected from: a polypeptide encoded by cDNA having one of nucleic acids of sequence number s 1-5; a polypeptide encoding a polynucleotide which is hybridized with cDNA having the one of nucleic acids of sequence numbers 1-5; a polypeptide encoded by gDNA having one or nucleic acids of sequence numbers 6-10; a polypeptide encoding the polynucleotide hybridized with the gDNA; or a polypeptide having an amino acid among amino acid sequences of sequence numbers 11-15.