METHOD OF PRODUCING EXPRESSION PLASMID VECTOR SHOWING HIGHER INHERITANCE STABILITY IN Escherihia coli CELLS

摘要

FIELD: medicine. ^ SUBSTANCE: stable inheritance effect is independent of an insertion position and orientation. The introduction of said sequence essentially reduces the loss frequency of both low-copy, and high-copy vectors. The given invention can find application in plasmid-bearing strain selection. And the cultivation of said strains does not require a selective medium to be used. ^ EFFECT: higher stability of vector inheritance. ^ 1 dwg, 1 tbl, 3 ex