| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to pharmacology and deals with method of obtaining microspheres from biodegradable polymer, including: addition of organic solvent to polymer, obtaining polymer solution (stage 1); dispersion of glucose level-regulating peptide in stage 1 polymer solution, obtaining medication dispersion and mixing alcohol or mixture of alcohol and organic acid with medication dispersion, obtaining solution with dispersed in it medication (stage 2); and obtaining microsphere from solution with dispersed in it stage 2 medication (stage 3), where glucose level-regulating peptide represents exedin-4 and where biodegradable polymer is selected from group, consisting of poly-L-lactic acid, D-lactic acid and glycolic acid copolymer, L-lactic acid and glycolic acid copolymer and D,L-lactic acid and glycolic acid copolymer. ^ EFFECT: invention ensures obtaining microsheres which demonstrate neither initial burst effect nor incomplete release, ensure release of medications of zero order and high efficiency of incapsulation and high stability. ^ 13 cl, 15 ex, 7 tbl, 5 dwg |
