CONJUGATES CALIHEAMICIN DERIVATIVE-CARRIER

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to field of biotechnology and deals with conjugates "caliheamicin derivative-carrier". Essence of invention includes methods of obtaining conjugates "monomer cytotoxic medication-caliheamicin/carrier" with considerably higher loading with medication than in earlier described methods, with low aggregation degree and with low content of low-conjugated fraction (LCF), as well as conjugates "cytotoxic medication-caliheamicin derivative/anti-CD22-antibody". Invention also includes compositions, which contain conjugate with CD22 antibody and application of said conjugates. ^ EFFECT: invention makes it possible to create conjugates with high loading of cytotoxic medication. ^ 181 cl, 11 ex, 13 tbl, 29 dwg