| 摘要 |
PURPOSE: A method for preparing a cephalosporin antibiotics intermediate using a novel enzyme is provided to industrially synthesize an acrystalline hydrate. CONSTITUTION: A method for preparing cephalosporin antibiotic intermediate of chemical formula 1 comprises: a step of adding cresol or phenol to a compound of chemical formula 2 and stirring to deprotecting a protection group of carboxyl groups; a step of adjusting pH concentration with a base, adding Sinta CLEC-PA enzyme, and deprotecting; and a step of adjusting pH concentration with inorganic acid. The base is a carbonate alkali metal, alkali metal hydroxide, ammonia solution, or trialkyl amine. |
