OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY

摘要

Provided is a compound useful as an endothelial lipase inhibitor. The compound is a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate of either. In formula (I), ring A is an aromatic carbocycle or an aromatic heterocycle; Z is -NR5-, -O-, or -S-; R5 is a hydrogen atom, an (un)substituted alkyl, an (un)substituted aryl, etc.; R1 is a hydrogen atom, a halogen atom, hydroxy, cyano, nitro, carboxy, an (un)substituted alkyl, etc.; R2 and R3 each independently is a hydrogen atom, a halogen atom, hydroxy, etc.; R4 is a group represented by the formula -(CR6R7)n-R8 (wherein R6 and R7 each independently is a hydrogen atom, a halogen atom, hydroxy, etc., n is an integer of 0-3, and R8 is carboxy, cyano, an (un)substituted alkyl, etc.); RX is a halogen atom, hydroxy, cyano, nitro, carboxy, an (un)substituted alkyl, etc.; and m is an integer of 0-3.