发明名称 |
SHIGA TOXIN B-SUBUNIT/CHEMOTHERAPEUTICS CONJUGATES |
摘要 |
The present invention relates to the use of a Shiga toxin B-subunit moiety as carrier for therapeutic agents, for example, anti-cancer agents such as anti-cancer agents that require intracellular uptake to exert their anti-cancer effects. In particular, the present invention provides conjugates comprising a Shiga toxin moiety covalently linked to an anti-cancer agent through a self-immolative spacer, and methods of using such conjugates to increase cellular uptake and/or specificity for cancer cells of the anti-cancer drug. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment.
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申请公布号 |
US2011152252(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
US20070958576 |
申请日期 |
2007.12.18 |
申请人 |
INSTITUT CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
JOHANNES LUDGER;EL ALAOUI ABDESSAMED;DECAUDIN DIDIER;ROBINE SYLVIE;SCHMIDT FREDERIC;FLORENT JEAN-CLAUDE |
分类号 |
A61K31/5513;A61K31/437;A61P35/00;C07D243/14;C07D491/14 |
主分类号 |
A61K31/5513 |
代理机构 |
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地址 |
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