发明名称 |
DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION |
摘要 |
The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs. |
申请公布号 |
WO2011075188(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
WO2010US40094 |
申请日期 |
2010.06.25 |
申请人 |
DICERNA PHARMACEUTICALS, INC.;BROWN, BOB, DALE |
发明人 |
BROWN, BOB, DALE |
分类号 |
C12Q1/68;A61K31/7088 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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