发明名称 |
HAEMOPHILUS INFLUENZAE TYPE IV PILI |
摘要 |
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
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申请公布号 |
US2011150889(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
US201113005166 |
申请日期 |
2011.01.12 |
申请人 |
NATIONWIDE CHILDREN'S HOSPITAL, INC. |
发明人 |
BAKALETZ LAUREN O.;MUNSON, JR. ROBERT S. |
分类号 |
A61K39/102;A61K31/7105;A61K39/00;A61K39/02;A61K39/395;A61P31/04;C07H21/04;C07K14/195;C07K14/285;C07K16/12;C12N15/31;C12N15/63;C12N15/74;C12Q1/68;G01N33/554 |
主分类号 |
A61K39/102 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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