DENDRITIC HIGH-MOLECULAR-WEIGHT POLYMER DRUG CARRIERS AND THEIR CONJUGATES WITH DRUGS ESPECIALLY FOR TREATMENT OF SOLID TUMOURS
摘要
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
申请公布号
WO2011072627(A2)
申请公布日期
2011.06.23
申请号
WO2010CZ00131
申请日期
2010.12.14
申请人
USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.;MIKROBIOLOGICKY USTAV AV CR, V.V.I.;ETRYCH, TOMAS;CHYTIL, PETR;STROHALM, JIRI;ULBRICH, KAREL;RIHOVA, BLANKA
发明人
ETRYCH, TOMAS;CHYTIL, PETR;STROHALM, JIRI;ULBRICH, KAREL;RIHOVA, BLANKA