发明名称 |
METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS |
摘要 |
The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with RNase III activity for generating siRNA mixtures or pools that effect RNAi, including the generation of a number of RNA molecules to the same target gene.
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申请公布号 |
US2011151558(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
US201113039653 |
申请日期 |
2011.03.03 |
申请人 |
LIFE TECHNOLOGIES CORPORATION |
发明人 |
BROWN DAVID;FORD LANCE P.;JARVIS RICH |
分类号 |
C12N5/00;A01K67/027;A61K31/713;A61K48/00;C12N5/10;C12N15/11;C12N15/63;C12Q1/68 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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