发明名称 |
Humanized Fc gamma R Mice |
摘要 |
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. |
申请公布号 |
US2011154512(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
US20100971080 |
申请日期 |
2010.12.17 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MACDONALD LYNN;TU NAXIN;GURER CAGAN;STEVENS SEAN;MURPHY ANDREW J. |
分类号 |
A01K67/027;C12Q1/18;G01N33/00;G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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