CRYSTAL OF RECOMBINANT INTERFERON WITH ALTERED SPATIAL CONFIGURATION, THREE-DIMENSIONAL STRUCTURE AND USES THEREOF

摘要

The present invention provides a crystal of recombinant interferon (rSIFN-co). The recombinant interferon has (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered three-dimensional structure as compared to IFN-alpha2b. The recombinant interferon of the present invention exhibits enhanced biological activities. The present invention also provides a structure model of the recombinant interferon which can be used for drug screening and/or drug design and the mimetic of the recombinant interferon.