TRANSDERMAL DELIVERY OF OLIGOSACCHARIDES

摘要

The present invention relates to a system for facilitating transdermal delivery of oligosaccharides comprising an apparatus that generates micro-channels in the skin of a subject and a skin patch comprising a pharmaceutical composition comprising as an active agent an oligosaccharide. Particularly, the composition comprises an oligosaccharide of 5-20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.