Method For Producing 3,7-Diaza-Bicyclo[3.3.1] Nonane Compounds

摘要

The invention relates to a one-pot reaction for the production of 3,7-diaza-bicyclo[3.3.1]nonane compounds, wherein in a first step a dicarboxylic acid ester is reacted with a pyridine aldehyde and a primary amine. The piperidone created in this manner is reacted with formaldehyde and a further primary amine in a second step. It is essential to the invention that both reaction steps are carried out in a one-pot variation in a C1-C4 alcohol as the solvent, and that the reaction water created is removed by means of distillation.