Therapeutic inhibition of ROR-1

摘要

A biological inhibitor of ROR-1 capable of inducing cell death or apoptosis in a cell expressing ROR-1 may comprise an antibody or other agent with affinity for the extracellular domain of ROR-1 or may comprise an agent with affinity for a ROR-1 nucleic acid. The therapeutic inhibition of ROR-1 (receptor tyrosine kinase-like orphan receptor 1) in cancers, particularly CLL (chronic lymphocytic leukaemia) by RNAi or using antibodies is disclosed.