| 摘要 |
The invention discloses a medicament comprising a therapeutically effective amount of a nitric oxide precursor for use in treating or preventing a disease in neonatal, premature infants, or infants selected from: disrupted ammonia clearance or arginine production; bone marrow transplant toxicity, hepatitis, sclerosis; impaired or damaged liver or gut tissue; deficiencies in N-acetyl glutamate production; increased ornithineicitrulline ratio levels resulting in severe lung dysfunction; hyperammonemia; hepatic micro-vasicular stenosis; necrosis resulting from valproic acid toxicity; impaired urea cycle function in newborn infants; deficiencies in CPSI function; persistent pulmonary hypertension in newborns (PPHN) or pulmonary hypertension, bone marrow transplant toxicity in a patient undergoing bone marrow transplant and combinations thereof, or subjects exposed to or about to be exposed to environmental stimulus selected from chemotherapy, cardiac surgery, increased oxidative stress, bone marrow transplant, and combinations thereof. |
