发明名称 |
PHL P 5A DERIVATIVES WITH REDUCED ALLERGENICITY AND RETAINED T-CELL REACTIVITY |
摘要 |
Variants (A) of group 5 allergens of the Pooideae that have, relative to the wild-type allergen (B), reduced immunoglobulin E reactivity but essentially unchanged reactivity with T lymphocytes. Independent claims are also included for the following: (1) DNA (I) that encodes (A); (2) recombinant expression vector (EV) that contains (I) and functionally linked expression control sequences; (3) host organisms transformed with (I) or EV; and (4) preparation of (A) by culturing the organisms of (3). ACTIVITY : Antiallergic. No details of tests for antiallergic activity are given. MECHANISM OF ACTION : Immunotherapy (hyposensitization); Vaccine. |
申请公布号 |
EP1629006(B1) |
申请公布日期 |
2011.06.22 |
申请号 |
EP20040739147 |
申请日期 |
2004.05.06 |
申请人 |
MERCK PATENT GMBH |
发明人 |
WALD, MARTIN;CROMWELL, OLIVER;NANDY, ANDREAS;KAHLERT, HELGA;WEBER, BERNHARD;FIEBIG, HELMUT |
分类号 |
C07K14/415;C12N15/82 |
主分类号 |
C07K14/415 |
代理机构 |
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代理人 |
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地址 |
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