发明名称 |
GENES ASSOCIATED WITH POSTTRAUMATIC-STRESS DISORDER (PTSD) |
摘要 |
<p>The present invention relates to a method of identifying a predisposition for developing posttraumatic stress disorder (PTSD) in a subject comprising assessing in a sample obtained from said subject the expression level of one or more genes selected from the FK506 binding protein 5 (FKBP5) gene, the signal transducer and activator of transcription (STAT5B) gene and the nuclear factor I/A (NFIA) gene, wherein a decrease in the expression level of said one or more genes as compared to the expression level of the corresponding gene(s) of a control is indicative of a predisposition for developing PTSD. Further, the invention relates to a method of identifying a compound capable of preventing or treating PTSD or capable of serving as a lead compound for developing a compound capable of preventing or treating PTSD and also to a method of selecting a therapy to prevent or treat PTSD.</p> |
申请公布号 |
EP2334816(A1) |
申请公布日期 |
2011.06.22 |
申请号 |
EP20090812717 |
申请日期 |
2009.09.14 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.;MOUNT SINAI SCHOOL OF MEDICINE OFFICE OF TECHNOLOGY |
发明人 |
HOLSBOER, FLORIAN;ISING, MARCUS;YEHUDA, RACHEL;BUXBAUM, JOSEPH D. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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