The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the "target" gene).
申请公布号
EP1546174(B1)
申请公布日期
2011.06.22
申请号
EP20030732052
申请日期
2003.01.22
申请人
COLD SPRING HARBOR LABORATORY
发明人
BERNSTEIN, EMILY;CAUDY, AMY;HANNON, GREGORY J.;PADDISON, PATRICK J.;CONKLIN, DOUGLAS;SCOTT, HAMMOND