发明名称 |
Methods and compositions for treatment of inflammatory disease using Cadherin-11 modulating agents |
摘要 |
<p>A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular functions of cadherin-11 such as cell proliferation, apoptosis, factor secretion, and binding of cadherin-11 to cadherin-11 counter-receptor inhibiting binding of cadherin-11 to its counter-receptor either in the context of a cell or in soluble form.
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申请公布号 |
EP2267029(A3) |
申请公布日期 |
2011.06.22 |
申请号 |
EP20100174749 |
申请日期 |
2000.09.01 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
BRENNER, MICHAEL;VALENCIA, XAVIER |
分类号 |
C07K16/28;A61K31/7088;A61K38/00;A61K38/17;A61K39/395;A61P19/02;A61P37/00;C07K14/705;G01N33/53;G01N33/577;G01N33/68 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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