摘要 |
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer. (see formula I)
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申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;JEIL PHARM. CO., LTD.;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;CJ CORP. |
发明人 |
CHEON, HYAE GYEONG;YOO, SUNG-EUN;KIM, SUNG SOO;YANG, SUNG-DON;KIM, KWANG-ROK;RHEE, SANG DAL;AHN, JIN HEE;KANG, SEUNG KYU;JUNG, WON HOON;PARK, SUNG DAE;KIM, NAM GEE;LEE, JANG HYUK;HUH, SUN CHUL;LEE, JAE MOK;SONG, SEOG BEOM;KWON, SOON JI;KIM, JONG HOON;LEE, JEONG-HYUNG;KIM, SEUNG JUN |