发明名称 |
MODIFIED ADENYLATE CYCLASE BORDETELLA CONTAINING CD11b/CD18 INTERACTION DOMAIN OR CD11B/CD18 INTERACTION DOMAIN DEFICIENT, AND ITS APPLICATION |
摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: group of inventions refers to medicine, namely to infectious diseases, and can be used for treating whooping cough and/or for Bordetella infection protection. Polypeptide under the invention represents a fragment of adenylate cyclase Bordetella containing CD11b/CD18 interaction domain from an amino acid sequence extended from position 1166 to position 1281 SEQ ID NO:1. Said invention also concerns the specific fragments of adenylate cyclase Bordetella containing CD11b/CD18 interaction domain, and to their application, particularly for targeting of molecules of interest to CD11b expressing cells. ^ EFFECT: use of the inventions allows extending the range of products for treatment and prevention of the Bordetella infection. ^ 26 cl, 9 dwg |
申请公布号 |
RU2421241(C2) |
申请公布日期 |
2011.06.20 |
申请号 |
RU20060101326 |
申请日期 |
2004.06.18 |
申请人 |
EHNSTITJU PASTEEHR;SANTR NAS'ONAL' DE LJA RESHERSH S'ENTIFIK |
发明人 |
LEKLERK KLOD;EHL'-AZAMI EHL'-IDRISSI MOKHAMMED;LADAN DANIEL';BOSH SESIL';SEBO PETER;LOUCHKA IRINA;OSICHKA RADIM |
分类号 |
A61K39/00;A61K39/10;A61K48/00;A61P11/00;A61P31/00;A61P31/04;C07K14/235;C12N5/12;C12N9/88;C12N15/60 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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