发明名称 |
INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS |
摘要 |
An insulin analogue comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The chlorinated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Chlorine substitution-based stabilization of insulin may reduce fibrillation and thereby enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration. |
申请公布号 |
WO2011072288(A2) |
申请公布日期 |
2011.06.16 |
申请号 |
WO2010US60085 |
申请日期 |
2010.12.13 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY;WEISS, MICHAEL |
发明人 |
WEISS, MICHAEL |
分类号 |
C07K14/62;A61K38/28;A61P3/10;C12N15/17 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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