发明名称 |
CDK5 INHIBITORS AND THERAPEUTIC USES THEREOF |
摘要 |
Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders. |
申请公布号 |
WO2011069334(A1) |
申请公布日期 |
2011.06.16 |
申请号 |
WO2010CN01982 |
申请日期 |
2010.12.07 |
申请人 |
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY;IP, NANCY YUK-YU;IP, FANNY CHUI-FUN;FU, WING YU;FU, GUANGMIAO |
发明人 |
IP, NANCY YUK-YU;IP, FANNY CHUI-FUN;FU, WING YU;FU, GUANGMIAO |
分类号 |
C07H3/04;A61K31/19;A61K31/352;A61K31/7004;A61K31/7016;A61P25/00;A61P25/28;A61P35/00;C07D311/08;C07H13/08 |
主分类号 |
C07H3/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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