MONOCLONAL ANTIBODIES THAT BIND B7H6 AND USES THEREOF
摘要
Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells.
申请公布号
WO2011070443(A1)
申请公布日期
2011.06.16
申请号
WO2010IB03411
申请日期
2010.12.08
申请人
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;PIERRES, MICHEL;VIVIER, ERIC;BARATIN, MYRIAM