HETEROLOGOUS EXPRESSION OF UREASE IN ANAEROBIC, THERMOPHILIC HOSTS
摘要
The invention is directed to the heterologous expression of urease in anaerobic thermophilic hosts, such as Thermoanaerobacterium, Thermoanaerobacter, and other related genera. For example, the anaerobic thermophilic host can be T. saccharolyticum. The host cells express the catalytic subunits of the urease enzyme together with the accessory proteins ureDEFG that facilitate protein folding and nickel activation. The invention further relates to the use of urea as a nitrogen source in the growth of microorganisms involved in consolidated bioprocessing systems.
申请公布号
WO2011071829(A2)
申请公布日期
2011.06.16
申请号
WO2010US59120
申请日期
2010.12.06
申请人
MASCOMA CORPORATION;SHAW, ARTHUR, J., IV;COVALLA, SEAN