SOLUBILIZATION METHOD FOR PARTIALLY SOLUBLE / INSOLUBLE ACTIVE SUBSTANCES THROUGH FORMATION OF OLIGOMER COMPOSITE

摘要

The present invention relates to a solubilization method for partially soluble / insoluble active substances through formation of an oligomer composite, wherein a structure having hydrophobic cavities is formed by using oligomers derived from two kinds of hydrophilic natural polymers, and the cavities are filled with a partially soluble / insoluble component, thereby inhibiting the self-aggregation of the partially soluble / insoluble substance and increasing thermodynamic stability to effectively solubilize the partially soluble / insoluble substance. The present invention comprises a first step of mixing oligomers derived from two kinds of hydrophilic natural polymers and dissolving the mixed oligomers in water to prepare an oligomer composite having a cavity structure; and a second step of adding a partially soluble / insoluble substance to the oligomer composite to fill the partially soluble / insoluble substance in the hydrophobic cavity structure of the oligomer composite.