发明名称 |
NANOPARTICLE FOR BIOMOLECULE DELIVERY |
摘要 |
A nanoparticle comprises a metal nanoparticle, e.g. gold, functionalised with at least one linker, the at least one linker comprising at least one first moiety capable of interacting with the metal nanoparticle, and at least one second moiety capable of interacting with at least one platinum group metal-based biologically active compound, e.g. a drug, wherein the molar ratio or capacity of platinum group metal-based biologically active compounds per nanoparticle is greater than (150). The present invention also relates to a method of preparing a nanoparticle according to the present invention. The present invention also relates to a biologically active nanoparticle comprising a nanoparticle according to the present invention, and at least one platinum group metal-based biologically active compound. The biologically active nanoparticle is more efficiently targeted to specific parts of the body, e.g. cancer cells, while reducing the side effects of the biomolecules being delivered. |
申请公布号 |
WO2010139942(A3) |
申请公布日期 |
2011.06.16 |
申请号 |
WO2010GB01070 |
申请日期 |
2010.06.01 |
申请人 |
UNIVERSITY OF STRATHCLYDE;GRAHAM, DUNCAN;WHEATE, NIAL, JOSEPH;BROWN, SARAH;CRAIG, GEMMA |
发明人 |
GRAHAM, DUNCAN;WHEATE, NIAL, JOSEPH;BROWN, SARAH;CRAIG, GEMMA |
分类号 |
A61K47/48;A61K41/00;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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